Weekly Digest
Weekly ToC Digest (week of 2026-10-26)
Based on the provided guidelines, only items pertinent to brain age modeling or closely related computational methods were selected, with a focus on neuroimaging and brain aging keywords. Other topics were deprioritized. The week’s highlights focus heavily on neuroimaging and computational methods related to brain aging and predictive modeling, consistent with user interests. Focusing on papers with significant brain age modeling and neuroimaging contributions. Papers selected based on relevance to brain aging, neuroimaging biomarkers, computational methods, and ML contributions. High preference given to brain aging models and harmonization techniques.
Included: 4 (score ≥ 0.35)
Scored: 12 total items
From micro-architecture to networks: canonical neurobiological architecture of functional brain organization across the lifespan and in psychopathology
bioRxiv
Score: 0.70
Published: 2026-10-26T00:00:00+00:00 Tags: brain age, MRI, multimodal, generalization
The study offers insights into functional brain network organization across the lifespan using large-scale fMRI data, potentially informing brain aging models.
RSS summary
Understanding how macroscale functional network connectivity (FNC) across the lifespan and in psychopathology is spatially organized with respect to microscale neurobiological architecture remains a challenge. Here, we constructed a cross-omics mapping framework by linking resting-state fMRI data (5,349 individuals, 6-80 years) with 49 neurobiological markers (24 cell types, 19 neurotransmitters, 6 mitochondria). We show that FNC development and aging unfold along cellular and molecular gradient…
Mapping the topographic organization of the human zona incerta using diffusion MRI
eLife
Score: 0.60
Published: 2026-10-23T00:00:00+00:00 Tags: MRI, neuroimaging
Uses diffusion MRI to explore brain structure, relevant for identifying neuroimaging-based biomarkers, though not specifically model-based.
RSS summary
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an ‘immensely confusing area about which nothing can be said’. Despite the elusive nature of this structure, mounting evidence supports the role of the ZI and surrounding regions across a diverse range of brain functions and as a candidate target for neuromodulatory therapies. Using in vivo diffusion magnetic resonance imaging and data-driven connectivity, we identify a topographic organization between the ZI a…
Cellular and mitochondrial correlates of regional glucose metabolism in the human cortex
bioRxiv
Score: 0.50
Published: 2026-10-25T00:00:00+00:00 Tags: MRI, neuroimaging, brain age
This study uses imaging techniques to correlate cellular composition with glucose metabolism, valuable for understanding energy demands in brain aging.
RSS summary
Regional differences in human brain glucose metabolism reflect local energy demands, but their cellular and mitochondrial determinants remain unclear. We combined [18F]FDG positron emission tomography in healthy human participants with estimates of cellular composition and mitochondrial density to unravel (sub)cellular correlates of heterogeneity in brain glucose metabolism. By correcting for RNA content and differential gene expression due to postmortem sampling, we addressed methodological sho…