Weekly Digest

Weekly ToC Digest (week of 2026-04-13)

Reviewed several papers for relevance to brain aging and computational modeling. Prioritized neuroimaging-based aging biomarkers and contributions to brain-age modeling. No items directly matched core interests in brain-age modeling or computational methodologies. Focus on computational methods and brain-aging models within the context of psychiatry and neuroimaging. No relevant items for brain aging, neuroimaging, or computational modeling this week.

Included: 3 (score ≥ 0.35)
Scored: 8 total items

Identification and Analysis of Novel RNA Editing Sites in Neurodegenerative Diseases Using Machine Learning Approaches.

bioRxiv
Score: 0.85
Published: 2026-04-13T00:00:00+00:00 Tags: machine learning, neurodegeneration

Involves machine learning methods to analyze RNA editing in neurodegenerative diseases, potentially connected to brain aging mechanisms.

RSS summary

ABSTRACT Background: RNA editing is a post-transcriptional modification that alters the sequence of an RNA transcript. Two types of RNA editing were found in mammals, involving the enzymatic deamination of either adenosine to inosine (A-to-I) or cytidine to uridine (C-to-U) nucleotides in RNA. A-to-I, which is the most common form of RNA editing, is mediated by the ADAR (adenosine deaminases acting on RNA) family of enzymes, ADAR1, ADAR2, and ADAR3. The editing event alters the hydrogen bond pai…

Age-dependent mitochondrial health decline in human induced neurons

bioRxiv
Score: 0.70
Published: 2026-04-13T00:00:00+00:00 Tags: aging, neurons

Focuses on aging-related decline in neurons, relevant for understanding aging mechanisms in brain cells.

RSS summary

In humans, aging is associated with an increased risk of developing neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. In neurons, the effect of aging on intrinsic molecular processes, and how they tie to age-related neurodegeneration remains unclear. Animal studies have shown that mitochondrial function decline, autophagy impairment and defective elimination of damaged mitochondria by mitophagy are all central features of neuronal aging. However, very few studies ha…